
Best supports to play with Vayne in LoL
If you’re wondering which champions you should be playing with Vayne, here are the five best supports to play alongside her in season 15.
The best supports for Vayne are champions that can either keep her alive through the early game or empower her late-game dueling and kiting potential.
Because of her short range and reliance on positioning, she pairs best with enchanters who can boost her survivability or peelers who create space in teamfights.
The most common picks are Lulu, Milio, and Thresh.
Soraka is a strong support if not countered by the enemy bot lane.
Avoid playing aggressive support champions with Vayne.

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The best supports to play with Vayne in LoL
Vayne has been rather unpopular in the last few seasons. Her kit didn’t really fit the meta, which led the devs to buff her up in recent times.
The recent changes to the anti laneswap meta have increased her priority as she cannot be punished as much as it did in the past.
While she got indirectly buffed by those changes, Vayne still requires great supports to have enough time to scale and reach her power spikes. Not all champions work well with her, and it’s crucial to know exactly which ones are better.
For that reason, we have compiled a list of the best supports to play alongside Vayne. By explaining their strength and weaknesses, you will know better how a specific duo functions.
Lulu – the no. 1 support for Vayne
When it comes to making Vayne a late-game carry, there are a few supports that can do it better than Lulu. Her entire kit is designed to empower and protect carries, and Vayne benefits from every part of it—attack speed boosts, shields, and the extra movement speed. The moment Vayne gets her core items, Lulu can make sure she can become the 1v9 threat every team wants to avoid
If things get rough, Lulu can always use her W on ultimate to keep her alive, creating windows for Vayne to quickly finish off the key targets. Paired with Vayne’s own mobility, it becomes incredibly tough to shut her down without chaining up lots of crowd controls.

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- Shields, speed, and CC perfectly complement Vayne’s kit
- Ultimate can clutch save her or turn fights around
- Enables hyper-aggressive late game teamfighting and kiting
- Makes Vayne scale even harder later in the game
Nami – The best Lulu alternative
Nami has been popping up quite often in the bot lane meta due to her being one of the best champions in the support tier list.
Alongside Vayne, Nami’s power is used to empower her short trading potential in the laning phase and help her survive the first few minutes with extra heals.
This should put Vayne into an easier position to scale up to her core items and get “online” faster. Later in the game, Nami’s goal is to keep on peeling for her ADC, utilizing her crowd control abilities to prevent enemies from shutting Vayne down.
Nami is mechanically slightly more demanding than Lulu and it also requires higher understanding of the laning phase to extract the maximum potential. Nonetheless, she’s currently one of the top choices to be played with Vayne.

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- Buffed autos make short trades extremely effective
- Sustain allows Vayne to play safer laning phases
- Good CC for both peel and setup
- Flexible in both poke lanes and engage comps
Thresh – the best engager support for Vayne
Thresh is one of the most versatile supports in the entire game, so it’s not a surprise to have him work well with Vayne.
Unlike the other two enchanters mentioned previously, Thresh comes with more kill pressure and playmaking potential. The Shadow Isles support will create room for Vayne to weave in attacks and short trades with her Tumble (Q) thanks to his hooks and Flay (E).
If you’re able to consistently find hooks onto the enemy opponents, you can even look to pick up a few kills early on and snowball. Later in the game, Thresh can use his abilities both defensively and aggressively, depending on the situation: pay attention to the enemy team composition and play reactively.

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- Lantern is a get-out-of-jail-free card in nasty situations
- Strong engage and disengage tools
- Sets up fights for Vayne with ease
- Lots of crowd controls to peel for her
Soraka – the meta support for Vayne
If Lulu is the type of champion to empower Vayne’s carry potential, then Soraka is the one who can make the carry nearly unkillable.
While she doesn’t provide shields or have many useful crowd controls, Soraka has enormous amounts of heals at all stages of the game, allowing Vayne to always be in a great state to take fights and skirmishes.
The longer the fights last, the stronger this combo gets. The enemies will be looking to shut Soraka down first, so watch out for your positioning. Additionally, Soraka can be punished quite heavily early on, so pick this as an answer to avoid getting countered. Champions like Blitzcrank can be extremely troublesome to deal with.

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- Constant healing allows Vayne to fight endlessly
- Ultimate can turn around teamfights
- Pairs well with Vayne’s kiting and duel potential
- Can be countered heavily so pick her only as an answer to enemy bot lane
Milio – boosting Vayne up
Ever since his release, it was quite evident that Milio was going to be a good champion with Vayne.
Aside from his shields and overall peeling potential, the great thing about Milio is his Cozy Campfire (W), which can extend Vayne’s auto attacks, allowing her to deal damage from a much safer distance. Moreover, he can cast his ultimate to cleanse incoming crowd controls, giving Vayne extra health and putting her in a position to kite the enemy team.
You will need lots of coordination, though, as the bot lane duo can be quite weak early on.

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- Extended range enhances Vayne’s DPS
- Ultimate can cleanse incomign crowd controls instantly
- Grants shields for better trading potential
- Weaker than average laning phase